WEBINAR on 4th World Forum on Infectious Diseases & Antimicrobial Resistance (IDAMR 2026) bringing together global experts to address one of the most pressing challenges in modern medicine. This premier gathering aims to explore groundbreaking research, innovative diagnostics, novel therapeutics, and public health strategies that are shaping the future of infectious disease management and the fight against antimicrobial resistance.
With its interdisciplinary sessions, IDAMR 2026 offers an outstanding platform for participants to engage in meaningful discussions, share cutting-edge advancements, and foster collaborations that extend beyond their field of expertise—ultimately enhancing knowledge, improving practice, and supporting professional growth.
This activity is designed for physicians, clinicians, internists, infectious disease specialists, microbiologists, virologists, bacteriologists, epidemiologists, immunologists, pharmacologists, nurses, nurse practitioners, physician assistants, hospitalists, public health professionals, pharmaceutical researchers, industry leaders, policy makers, academicians, scholars, residents, and students, along with delegate participation from organizations including universities, research institutes, pharmaceutical and biotechnology companies, and healthcare associations.
about IDAMR 2026 conference
Dear Esteemed Colleagues,
It is our distinct honor to invite you to participate in the 4th World Congress on Infectious Diseases and Antimicrobial Resistance (IDAMR 2026), taking place on June 25–26, 2026 in London, UK. In an era where infectious diseases continue to challenge global health systems and antimicrobial resistance (AMR) threatens modern medicine, IDAMR 2026 stands as a vital international platform for evidence-based solutions and strategic collaboration.
Why Your Participation Matters Now
Antimicrobial resistance could cause 10 million deaths annually by 2050 and cost the global economy up to USD 100 trillion without urgent action. Meanwhile, the infectious disease diagnostics market is projected to exceed USD 40 billion by 2028, with rising global investments in surveillance, vaccines, and antimicrobial stewardship driven by emerging infections and post-pandemic preparedness.
IDAMR 2026 directly addresses these urgent global priorities, offering a high-impact environment where science meets strategy and innovation meets implementation.
What You Gain by Attending
We warmly welcome you to join us in London this June and contribute to advancing transformative solutions in infectious diseases and antimicrobial resistance.
With sincere regards,
Organizing Committee
IDAMR 2026 | World Forum on Infectious Diseases
701 West Georgia Street | Suite 1500, Vancouver, V7Y 1C6, Canada
University of Minnesota, USA
Saint Xavier University, USA
The Data and Analytics Innovation Institute, USA
Columbia University, USA
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Infectious Diseases and Antimicrobial Resistance Market Overview:
The infectious diseases and antimicrobial resistance (AMR) market is growing as drug-resistant infections rise worldwide. The antibiotic resistance segment is valued at USD 9.3 billion in 2025 and projected to reach USD 12.1 billion by 2030 (CAGR 5.5%). Growth is fueled by increasing cases, public–private funding, and regulatory support. Asia-Pacific leads the market, South America shows the fastest growth, and pneumonia remains the largest disease segment.
The AMR diagnostics market, worth USD 4.6 billion in 2024, is expected to hit USD 6.7 billion by 2030 (CAGR 6.6%). Demand is rising for rapid, point-of-care tests, especially PCR-based technologies. North America currently dominates, but India and other emerging economies are expanding quickly, driven by the need for early detection and better antibiotic stewardship.
The AMR surveillance market is valued at USD 6.24 billion in 2025 and forecasted to reach USD 8.23 billion by 2030 (CAGR 5.7%). Growth is driven by molecular diagnostics, AI-powered analytics, and government programs. North America holds the largest share, while Asia-Pacific is the fastest-growing region. Hospitals remain the main users, with diagnostic labs gaining momentum.
Target Audience:
Physicians | Internists | Clinicians | Infectious Disease Specialists | Microbiologists | Virologists | Bacteriologists | Parasitologist | Medical Students, Researchers, Residents Epidemiologists | Immunologists | Pharmacologists |Antimicrobial Stewardship Experts | Infection Control Officers | Healthcare Practitioners, Nurses | Allied Health Professionals, Physician Assistants | Pharmaceutical Researcher | Drug Discovery Scientists, Clinical Laboratory Scientists | Laboratory Technicians, Hospitals, Medical Colleges | Research Institutes, Pharmaceutical Industries | Biotechnology Companies, Drug Manufacturing Companies | Healthcare Workers and Druggist | Industries
Infectious Diseases and Antimicrobial Resistance Market Overview in USA:
The U.S. infectious diseases market is one of the most advanced globally, valued at over USD 24 billion in 2025, with a projected CAGR of 6–7% through 2030. Growth is driven by increasing hospital-acquired infections (affecting nearly 1 in 31 patients daily, CDC) and viral threats such as influenza, RSV, and COVID-19 variants. The U.S. for a significant share of global revenues, with the influenza vaccine market alone expected to exceed USD 6.5 billion by 2028. Advanced diagnostic platforms, particularly rapid molecular tests, also expanding at a CAGR of nearly 9%, reflecting the demand for early detection and containment of outbreaks. Antimicrobial resistance remains a major challenge, causing 2.8 million infections and 35,000 deaths annually in the U.S. (CDC, 2023).
Valued at USD 3.5–4 billion in 2025, and expected to grow at a CAGR of 5% due to rising resistance in pathogens such as E. coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Federal funding has increased, with initiatives like CARB-X awarding over USD 360 million to early-stage AMR projects and BARDA investing more than USD 1 billion in advanced-stage antibiotic and diagnostic development. Rapid diagnostic tests for AMR are also gaining traction, with adoption projected to grow 2x by 2030.
Looking ahead, the U.S. infectious diseases and AMR market is poised for steady expansion, projected to reach USD 33–35 billion by 2030. Government incentives such as the FDA’s QIDP designation, which provides market exclusivity and priority review for new antibiotics, are encouraging innovation. However, the market faces hurdles: the average cost of antibiotic R&D exceeds USD 1.5 billion, while uptake remains slow due to stewardship programs and reimbursement challenges. Despite these barriers, strong federal support and industry investment position the U.S. as a global leader in infectious disease management, with increasing focus on next-generation antibiotics, vaccines, and precision diagnostics to combat AMR.
Infectious Diseases and Antimicrobial Resistance Market Overview in Europe:
The commercial landscape in Europe is being reshaped by hard epidemiology and rising stewardship pressure. AMR is linked to 35,000+ deaths every year in the EU/EEA and an estimated 865,000+ resistant infections annually; the economic drag is ~€11.7 billion per year (PPP) across EU/EEA economies, a recurrent burden that continues to justify spend on novel antibiotics, rapid diagnostics, and infection-prevention solutions. On the demand side, antibiotic consumption fell sharply by 17% from 2018 to 2021, then rebounded to 19.8 DDD/1,000/day in 2023 (vs. 20.1 in 2018)—signalling renewed utilization post-pandemic and exposing variation across member states that vendors must factor into go-to-market plans. In 2023, about 90% of use sat in the community (18.3 DDD/1,000/day) versus 1.6 in hospitals, keeping primary care channels central for stewardship tech and point-of-care diagnostics.
Policy and funding are strong tailwinds. The 2023 EU Council Recommendation sets One-Health targets on IPC, stewardship and national action plan execution, while the Commission and ECDC ramp guidance and monitoring—creating compliance-driven demand for surveillance and IPC solutions. The EU’s health security arm HERA commands ~€2.8 billion (EU4Health) and ~€1.7 billion (Horizon Europe) for 2022–2027, and recent calls include a €13 million instrument for rapid point-of-care susceptibility testing—clear signals for diagnostics innovators. For 2025 specifically, the EU4Health work programme allocates €357.6 million to HERA actions, with procurement and grants as key vehicles—relevant for scale-up pathways and public tenders. amplify transmission of resistant pathogens. Together, these drivers underscore both the urgency of policy and market interventions and the strong opportunity for solutions spanning novel antibiotics, rapid diagnostics, infection-control systems, and stewardship programs. high population density and poor sanitation.
Market access is also moving: Europe has approved new agents (e.g., Emblaveo and Exblifep) for difficult Gram-negative infections, expanding the treatable addressable market while emphasizing antimicrobial stewardship frameworks at launch. Meanwhile, lawmakers debate transferable exclusivity vouchers (TEVs) as a pull incentive—industry sees them as catalytic, while public-health groups raise affordability and spillover concerns. Whichever design prevails, a predictable EU pull-incentive is the swing factor for late-stage pipeline investment and partnering decisions through 2030.
Infectious Diseases and Antimicrobial Resistance in Asia:
The infectious diseases and antimicrobial resistance (AMR) market in Asia is expanding rapidly, driven by rising infection rates, high antibiotic misuse, and increasing healthcare investments. The Asia-Pacific antibiotic resistance market was valued at USD 2.34 billion in 2023 and is projected to reach USD 3.57 billion by 2030, reflecting a CAGR of about 6.2%. In parallel, the AMR diagnostics segment is expected to grow from USD 1.05 billion in 2024 to USD 1.64 billion in 2030, at a 7.8% CAGR, while the antimicrobial susceptibility testing (AST) market is forecast to expand from USD 627.6 million in 2023 to USD 967.5 million by 2030 (CAGR 6.4%). These figures show that Asia is becoming a key growth hub for both therapeutic and diagnostic solutions in AMR, reflecting both the severity of the regional burden and growing demand for stewardship technologies.
The health burden of AMR in Asia is particularly severe. Globally, 5 million deaths in 2019 were linked to AMR, of which 1.27 million were directly attributable. South Asia recorded some of the world’s highest mortality, with 21.5 deaths per 100,000 population due to AMR, while Southeast and East Asia saw 11.7 per 100,000. In the WHO South-East Asia Region alone, sepsis accounted for 4 million deaths in 2019, and up to 1.41 million of these were linked to bacterial AMR. For India, the estimated toll was 297,000 deaths from resistance in a single year. Resistance trends are worsening: between 2016 and 2021, E. coli susceptibility to imipenem fell from 86% to 64%, while Klebsiella pneumoniae dropped from 65% to 43%. In 2021, carbapenem resistance in Acinetobacter baumannii reached 87.5%, and methicillin-resistant Staphylococcus aureus (MRSA) rose from 28.4% to 42.6% over the same period.
Behavioral and systemic factors continue to accelerate resistance across Asia. Self-medication rates for antibiotics range from 9% to 62% across the region, often linked to misconceptions about their effectiveness against viral infections like colds and flu. In Indonesia, around 75% of respondents believed antibiotics could treat viral illnesses, while in China, more than half of people reported antibiotic use within six months, with about 5% sourcing drugs online. Meanwhile, the agricultural sector is a major contributor: antibiotic use in animal husbandry across China and India is projected to double by 2030, creating spillover risks into human populations. The pace of urbanization is another driver, with Asia expected to host 27 of the world’s 43 megacities by 2030.
Universities and Research Institutes:
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EUROPE
University of Oxford / University of Cambridge / Imperial College London / University College London / London School of Hygiene & Tropical Medicine / King’s College London / University of Edinburgh / University of Glasgow / University of Manchester / University of Copenhagen / University of Aarhus / University of Helsinki / University of Turku / Karolinska Institute / Uppsala University / Stockholm University / University of Gothenburg / Lund University / University of Oslo / University of Bergen / University of Amsterdam / Leiden University / Utrecht University / Erasmus University Rotterdam / Radboud University Nijmegen / University of Groningen / University of Paris-Saclay / Sorbonne University / Pasteur Institute Paris / University of Strasbourg / University of Geneva / University of Lausanne / University of Zurich / ETH Zurich / University of Basel / University of Vienna / Medical University of Vienna / University of Munich (LMU) / Technical University of Munich (TUM) / University of Heidelberg / Charité – Universitätsmedizin Berlin
Asia/Middle East
University of Tokyo / Kyoto University / Osaka University / Tohoku University / Nagoya University / Keio University / National University of Singapore / Nanyang Technological University / Singapore University of Technology and Design / Chinese University of Hong Kong / University of Hong Kong / Peking University / Tsinghua University / Fudan University / Shanghai Jiao Tong University / Zhejiang University / Sun Yat-sen University / Seoul National University / KAIST – Korea Advanced Institute of Science & Technology / Yonsei University / Korea University / Indian Institute of Science, Bangalore / All India Institute of Medical Sciences, New Delhi / University of Delhi / Banaras Hindu University / King Saud University / King Abdulaziz University / Weill Cornell Medicine – Qatar / Qatar University / American University of Beirut / Tel Aviv University / Hebrew University of Jerusalem / University of Tehran / Sharif University of Technology / University of Jordan / Kuwait University / Sultan Qaboos University / United Arab Emirates University / King Fahd University of Petroleum & Minerals/ University of Baghdad
Hospital and Medical centers
USA
Mayo Clinic / Massachusetts General Hospital / Brigham and Women’s Hospital / UCSF Medical Center / University of Michigan Hospitals and Health Centers / Mount Sinai Hospital, New York / NewYork Presbyterian Hospital / Memorial Sloan Kettering Cancer Center / Stanford Health Care / Duke University Hospital / University of Pennsylvania Health System / Northwestern Memorial Hospital / Vanderbilt University Medical Center / University of Washington Medical Center / University of Chicago Medical Center / Cedars-Sinai Medical Center / Baylor University Medical Center / Rush University Medical Center / University of Pittsburgh Medical Center / Emory University Hospital / Indiana University Health Medical Center / University of California, Los Angeles Medical Center / University of Texas Southwestern Medical Center / Cleveland Clinic Florida / Hospital of the University of Pennsylvania / Oregon Health & Science University Hospital / University of Colorado Hospital / Mount Sinai Beth Israel / NYU Langone Health / Mayo Clinic Phoenix Henry Ford Health System / University of Iowa Hospitals and Clinics / University of Minnesota Medical Center / University of North Carolina Hospitals / Thomas Jefferson University Hospitals / University of Kentucky Albert B. Chandler Hospital
EUROPE
Charité – Universitätsmedizin Berlin / University Hospital Heidelberg / University Hospital Munich (LMU) / University Hospital Hamburg-Eppendorf / University Hospital Frankfurt / University Hospital Cologne / University Hospital Leipzig / Karolinska University Hospital, Stockholm / Sahlgrenska University Hospital, Gothenburg /Uppsala University Hospital / Rigshospitalet, Copenhagen / Odense University Hospital /Aarhus University Hospital / University Hospital Zurich / University Hospital Basel /University Hospital Basel / University Hospital Geneva / Lausanne University Hospital / University Hospital Vienna / Medical University of Vienna Hospital / University Hospital Paris-Saclay / Saint-Louis Hospital, Paris / Assistance Publique – Hôpitaux de Paris (AP-HP) / University Hospital Strasbourg / University Hospital Bordeaux / University Hospital Lyon / University Hospital Grenoble / University Hospital Lille / University Hospital Toulouse / University Hospital Marseille / University Hospital Leuven, Belgium / University Hospital Ghent, Belgium / Erasmus MC, Rotterdam / Amsterdam University Medical Center / Leiden University Medical Center / Utrecht University Medical Center / Radboud University Medical Center / University Hospital Oslo / University Hospital Bergen
Asia/Middle East
The University of Tokyo Hospital / Kyoto University Hospital / Osaka University Hospital / Tohoku University Hospital / Nagoya University Hospital / Keio University Hospital / National University Hospital, Singapore /Singapore General Hospital / Tan Tock Seng Hospital, Singapore / Chinese University of Hong Kong Medical Centre /Queen Mary Hospital, Hong Kong / Peking University First Hospital / Peking Union Medical College Hospital / Fudan University Zhongshan Hospital / Ruijin Hospital, Shanghai / Zhejiang University Sir Run Run Shaw Hospital / Sun Yat-sen University First Affiliated Hospital / Seoul National University Hospital / Asan Medical Center, Seoul / Samsung Medical Center, Seoul / Yonsei University Severance Hospital / India – All India Institute of Medical Sciences (AIIMS), New Delhi / Christian Medical College (CMC), Vellore / King Faisal Specialist Hospital & Research Centre, Riyadh / King Khalid University Hospital, Riyadh / King Abdulaziz University Hospital, Jeddah / Weill Cornell Medicine – Qatar / Hamad Medical Corporation, Qatar / American University of Beirut Medical Center /Hadassah Medical Center, Jerusalem /Sheba Medical Center, Tel Aviv /Tel Aviv Sourasky Medical Center / Shariati Hospital, Tehran / Tehran University Medical Center / King Hussein Cancer Center, Jordan / Royal Medical Services, Jordan / Sultan Qaboos University Hospital, Oman / United Arab Emirates University Hospital / Cleveland Clinic Abu Dhabi
Companies and Industries
USA
Pfizer / Moderna / Johnson & Johnson / Merck & Co. / Gilead Sciences / Amgen / Biogen / Regeneron Pharmaceuticals / Bristol-Myers Squibb / Eli Lilly and Company / Vertex Pharmaceuticals / Novavax / AbbVie / Genentech / Illumina / Thermo Fisher Scientific / Bio-Rad Laboratories / Emergent BioSolutions / Inovio Pharmaceuticals / ModernaTX / Vir Biotechnology / Moderna Therapeutics / Moderna Biotech / Moderna Inc / Moderna Labs / Moderna Research / Moderna Vaccine Division / Moderna Therapeutics Inc / Moderna Biologics / Moderna Immunology / Moderna Clinical / Moderna BioTech / Moderna Pharma / Moderna R&D /Moderna Healthcare / Moderna Development / Moderna Innovations / Moderna Global
EUROPE
GlaxoSmithKline (GSK), UK / AstraZeneca, UK / Bayer AG, Germany / Novartis, Switzerland / Roche, Switzerland / Sanofi, France / BioNTech, Germany / BioNTech, Germany / Lonza Group, Switzerland / Merck KGaA, Germany / Boehringer Ingelheim, Germany / UCB Pharma, Belgium / Ipsen, France / CSL Behring, Switzerland / Evotec, Germany / Valneva, France / Oxford Biomedica, UK / Abcam, UK / Qiagen, Netherlands / Vectura Group, UK / Galapagos NV, Belgium / Genmab, Denmark / Moderna Europe / CureVac, Germany / Bavarian Nordic, Germany / Seqirus, UK / Morphosys, Germany / BioMerieux, France / Sartorius, Germany / Nabriva Therapeutics, Austria / Orion Corporation, Finland / MedImmune, UK / Adaptimmune, UK / Horizon Discovery, UK / Exscientia, UK /Oxford Nanopore Technologies, UK / Syncona, UK /Cytiva, Sweden / Evaxion Biotech, Denmark / Moderna Switzerland
Asia/Middle East
Samsung Biologics, South Korea / Celltrion, South Korea /LG Chem Life Sciences, South Korea / Takeda Pharmaceutical, Japan / Daiichi Sankyo, Japan / Astellas Pharma, Japan / Fujifilm Diosynth Biotechnologies, Japan / Shionogi & Co., Japan / Eisai Co., Japan / Bharat Biotech, India / Serum Institute of India, India / Zydus Cadila, India / Dr. Reddy’s Laboratories, India / Lupin Limited, India / Biocon, India / WuXi AppTec, China / Sinovac Biotech, China / CanSino Biologics, China / Beijing Institute of Biotechnology, China / Shanghai RAAS Blood Products, China / Shanghai Fosun Pharma, China / China National Biotec Group (CNBG), China / Moderna China / CureVac Asia / BioNTech Asia / Boehringer Ingelheim Asia / G42 Healthcare, UAE / Julphar Pharmaceuticals, UAE / Hikma Pharmaceuticals, Jordan / King Faisal Specialist Hospital & Research Centre Biotech, Saudi Arabia / Saudi Vaccine & Biotech Center / Qatar Biomedical Research Institute / Weill Cornell Medicine – Qatar Biotech / Teva Pharmaceuticals Middle East / Biologix, Israel / Pluristem Therapeutics, Israel / Evogene, Israel / Redhill Biopharma, Israel / Moderna Middle East
Societies and Associations
USA
American Society for Microbiology (ASM) / American Society for Virology (ASV) / American Society for Immunology (ASI) / American Association of Immunologists (AAI) / Society for Immunotherapy of Cancer (SITC) / Federation of American Societies for Experimental Biology (FASEB) / American Pathology Association / College of American Pathologists (CAP) / American Society for Clinical Pathology (ASCP) / Infectious Diseases Society of America (IDSA) / Society for Healthcare Epidemiology of America (SHEA) / American College of Allergy, Asthma & Immunology (ACAAI) / American College of Rheumatology (ACR) / American Society of Hematology (ASH) / Society for Leukocyte Biology (SLB) / Association of Pathology Chairs (APC) / Society for Experimental Biology and Medicine (SEBM) / Clinical Immunology Society (CIS) /American Association of Veterinary Laboratory Diagnosticians (AAVLD) / Society for Mucosal Immunology (SMI) / American College of Medical Genetics and Genomics (ACMG) / Association for Molecular Pathology (AMP) / Society for Pediatric Research (SPR) / American Society for Blood and Marrow Transplantation (ASBMT) / American College of Surgeons – Pathology Section / American Society for Investigative Pathology (ASIP) / Society for Immunotherapy of Cancer (SITC) / American College of Clinical Pharmacy – Immunology / American College of Clinical Pharmacy – Immunology / American College of Allergy, Asthma & Immunology (ACAAI) / Society for Virology Research / American College of Toxicology (ACT) / American Society for Bone and Mineral Research (ASBMR) / American College of Neuropsychopharmacology (ACNP) / American Society of Transplantation (AST) / American Heart Association – Immunology Section / American Diabetes Association – Immunology Section / Association for Pathology Informatics (API) / Society for Experimental Biology and Medicine (SEBM) / American College of Physicians – Pathology Section /
EUROPE
Immunology (EAACI) / European Society for Organ Transplantation (ESOT) / European Society of Clinical Immunology (ESCI) / European Society for Blood and Marrow Transplantation (EBMT) / European Society of Paediatric Infectious Diseases (ESPID) / European Society of Human Genetics (ESHG) /European Society for Gene and Cell Therapy (ESGCT) / European Society for Immunotherapy of Cancer (ESIC) /European Federation of Immunological Societies (EFIS) / European Society for Clinical Virology (ESCV) / European Society for Experimental Biology (ESEB) / European Society for Immunopathology (ESIP) /European Society for Laboratory Medicine (ESLM) / European College of Veterinary Pathologists (ECVP) / European Society for Molecular Imaging (ESMI) / European Society for Clinical Virology and Immunology (ESCVI) / European Society of Transplantation Immunology Section (EST-IS) / European Society for Paediatric Allergy and Immunology (ESPAI)
Asia/Middle East
Asian Society for Virology (ASV) / Asia Pacific Society for Immunology (APSI) / Japanese Society for Immunology (JSI) / Indian Immunology Society (IIS) / Indian Association of Pathologists and Microbiologists (IAPM) / Korean Society for Immunology (KSI) / Chinese Society for Immunology (CSI) / Chinese Society for Microbiology (CSM) / Taiwan Society for Microbiology and Immunology (TSMI) / Thai Society for Immunology (TSI) / Singapore Immunology Network (SIgN) / Hong Kong Society for Microbiology (HKSM) / Saudi Society for Microbiology and Infectious Diseases (SSMID) / Saudi Society for Pathology (SSP) /Israeli Society for Microbiology (ISM) / Qatar Biomedical Research Society (QBRS) / Emirates Society for Immunology (ESI) / UAE Society for Pathology and Laboratory Medicine (UAE SPLM) / Turkish Society of Microbiology and Immunology (TSMI) /
Societies and Associations
USA
EUROPE
Asia/Middle East
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Deterministic thinking has recognised the influence that the environment has on the spread of diseases (Armocida & Rigo, 2013). Today, however, global warming (Apat, 2007) and globalisation have led to other factors (genetic, pollutants, behavioural and lifestyle) altering the correct relationship between society, the environment and health, changing the approach to medicine and accessibility to related healthcare facilities. In the case of infectious diseases, the pervasiveness of viruses in different social spheres forces us to re-examine the phenomenon epistemologically. In line with the 'integrated and unifying' approach set out in the One Health Joint Plan of Action (FAO, UNEP, WHO & WOAH, 2022), the scientific community is responsible for adopting a holistic approach to understanding the causes of pathological processes, and for identifying appropriate and timely mitigation and adaptation measures. From this perspective, geography's integrated and multiscale approach can be valuable (Palagiano & Pesaresi, 2011). Social, economic, environmental and biological changes are accelerating the spread of exotic animal species that become vectors of new pathogens (Bologna, 2023) for which communities are unprepared (Rossati & al., 2014). We therefore propose a multidimensional analysis that integrates clinical, spatial, socio-demographic and environmental data to investigate the spread of infectious diseases in Italy. Particular attention is paid to the effects of changing geo-environmental conditions. Clustering is paid to assess the impacts of global warming, demographic trends - including tourist flows and migration (legal and illegal) -, the inequalities induced by different lifestyles and different sanitary conditions, and gender differences, in order to present an epidemiological map that can highlight the spatial distribution of infectious outbreaks across the country. In this way, areas at risk are identified and evidence is gathered that can be used to develop policies aimed at preventing, containing and mitigating the spread of disease.
Aquaculture of Nile tilapia (Oreochromis niloticus) has faced challenges from pathogens such as the emerging bacterium Lactococcus garvieae. Humic acid (HA) was used as a prophylactic measure to evaluate its effect on the intestinal microbiota, immune system, and survival in tilapia challenged with L. garvieae under laboratory conditions. Four concentrations of HA were tested in feed over 83 days. The intestinal microbiota was analyzed in treatment IV (1.0 g/ kg of feed) and control through 16S rRNA gene sequencing (V3). Liver and gill tissue were collected for immune system gene expression analysis (COX-2, TGF, IL-1B, and TNF-?) through real-time qPCR methods. On day 71, the fish were inoculated by immersion with L. garvieae (CL50 = 8.5 × 105 CFU/mL). Gene expression in the liver (COX-2 and TNF?) and gills (COX-2, TGF-?, and IL-1?) increased significantly in treatment IV. Cetobacterium was among the most abundant genera in the tilapia gut. Fusobacteriota (phylum) and the genera Aeromonas, Rhodobacter, Gemobacter, and Ideonella were enriched in HA, whereas the phylum Patescibacteria and genera Pelomonas, Nitrobacter, and Clostridioides decreased significantly. Dietary HA supplementation significantly altered gut microbiota diversity and the interaction network core. In channel cat?sh (Ictalurus punctatus), dietary HA supplementation signi?cantly altered gut microbiota alpha diversity (Oladipupo et al. 2024). Our results in tilapia showed that, while Shannon and Simpson indices (re?ecting both richness and evenness) showed no signi?cant di?erences between HA and control group, the Chao1 and ACE indices (estimating species richness) were signi?cantly higher in HA- treated ?sh. Humic acid supplementation significantly improved tilapia survival against L. garvieae by enhancing immune gene expression and modulating gut microbiota—enriching Fusobacteriota and beneficial genera (Rhodobacter, Ideonella) while reducing pathogens (Pelomonas, Clostridioides). These findings support HA as a prophylactic alternative against lactococcosis in Nile tilapia (O. niloticus) farming.
BACKGROUND: The management of pediatric vesicoureteral reflux (VUR) frequently relies on long-term antibiotic prophylaxis to prevent renal damage. Standard monitoring via voiding cystourethrography (VCUG) involves ionizing radiation, which often leads to delayed follow-up intervals. This prolonged waiting period unnecessarily extends antibiotic exposure, significantly contributing to the global antimicrobial resistance (AMR) crisis. OBJECTIVES: To evaluate the efficacy of radiation-free contrast-enhanced ultrasound (CEUS) in implementing accelerated follow-up protocols and reducing the duration of antibiotic prophylaxis in children. METHODS: In this prospective study (2019–2024), 1,050 children (aged 1–15 years) were enrolled. Patients with Grade III–V VUR were reassessed using contrast-enhanced voiding urosonography (ceVUS) at 12 months, instead of the conventional 24-month radiographic protocol. RESULTS: Among the 675 patients with confirmed VUR, the 12-month ceVUS follow-up revealed complete resolution in 47.2% of males and 39.6% of females. A significant downgrading of the reflux grade occurred in approximately 25% of cases. As shown in Table 1, these findings enabled the safe discontinuation of antibiotic prophylaxis in 70.8% of male and 66% of female patients. Furthermore, ceVUS demonstrated a superior diagnostic yield compared to traditional methods.